Showing posts with label of. Show all posts
Showing posts with label of. Show all posts

Tuesday, June 13, 2017

Its the most wonderful time of the year!

Its the most wonderful time of the year!


Its mid July and while the normal folks are busy planning trips to the lake and having BBQs we horror fanatics and monster kids are scouring store aisles waiting for that first bit of Halloween merchandise to rear its orange, ugly head.  The first sighting a grinning pumpkin means the cool, crisp Autumn air is soon to follow.  Aisles full of backpacks and brightly colored markers will get replaced with jack-o-lanterns and skeletons.  Its truly the best time to be a horror nut.

So what have I found so far?  Not a lot.  But what I have seen has been quality which makes me think that were in for a great Halloween season!

Gordmans




At Home (formally Garden Ridge)

Michaels



As July comes to an end you can expect more posts dedicated to further Halloween-related merchandise.  As Ive relocated to a new state this year Im realling looking forward to checking out what Albuquerque has to offer this season. 

For further updates be sure to follow @Cannibalreviews on Instagram, Twitter, and Tumbler.  For those also located in the Southwest Im currently working on a facebook page that can bring like-minded individuals together to share news on upcoming local events and Halloween related activities.

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Sunday, June 11, 2017

IV VITAMIN C WILL STOP GROWTH OF AGGRESSIVE FORMS OF CANCER

IV VITAMIN C WILL STOP GROWTH OF AGGRESSIVE FORMS OF CANCER





High-dose vitamin C has been studied as a treatment for patients with cancer since the 1970s. It can completely shut down specific types of tumors. According to a new study from Weill Cornell Medicine investigators, scientists could one day harness vitamin C to develop targeted treatments.
Vitamin C has a broad spectrum antioxidant function with the ability to protect cell structures and DNA from free radical damage. It is remarkably safe even in enormously high doses. Compared to commonly used prescription drugs, side effects are virtually nonexistent. No matter how high the concentration, vitamin C does not harm healthy cells. Yet, through an array of enzymatic and metabolic reactions, vitamin C has an impressive ability to protect and treat and wide range of diseases, including cancer.
Colorectal cancer is the third most-common cancer diagnosed in the United States, with about 93,090 new cases each year. Around half of those cases harbor mutations in specific KRAS and BRAF genes; these forms of the disease are more aggressive and don’t respond well to current therapies or chemotherapy.
In a recent study published in Science, a team of researchers from Weill Cornell Medicine, Cold Spring Harbor Laboratory, Tufts Medical Center, Harvard Medical School and The Johns Hopkins Kimmel Cancer Center found that high doses of vitamin C — roughly equivalent to the levels found in 300 oranges — impaired the growth of mutant colorectal tumors in cultured cells and mice. The findings could lead to the development of new natural treatments and provide critical insights into who would most benefit from them.
The benefits of long-term vitamin C consumption in excess of the U.S. government recommended daily allowance (RDA) are widely acknowledged and include reduced risks of cancer, cardiovascular disease and cataracts. Higher-than-RDA vitamin C intakes have been associated with increases in good HDL cholesterol, decreases in LDL cholesterol oxidation, decreased blood pressure and decreased cardiovascular mortality.
The first physician to aggressively use vitamin C to treat disease was Frederick R. Klenner, M.D., beginning in the early 1940s. Dr. Klenner successfully treated chicken pox, measles, mumps, tetanus and polio with huge doses of vitamin C. He used massive doses of vitamin C for more than 40 years of family practice. Many practioners who practice with IV vitamin C consider the treatment more effective than any vaccine ever invented.
“Our findings provide a mechanistic rationale for exploring the therapeutic use of vitamin C to treat colorectal cancers that carry KRAS or BRAF mutations,” said senior author Dr. Lewis Cantley, the Meyer Director of the Sandra and Edward Meyer Cancer Center and the Margaret and Herman Sokol Professor in Oncology Research at Weill Cornell Medicine.
Laboratory studies have shown that high doses of vitamin C may slow the growth and spread of prostate, pancreatic, liver, colon, and other types of cancer cells
The second mechanism of action is actually a pro-oxidant effect. Doses above 15 grams are proven to have a “pro-oxidant” effect by generating hydrogen peroxide, which in turn selectively destroys cancer cells. High doses of vitamin C are preferentially delivered to the areas surrounding the tumour because the vitamin molecule looks similar to a sugar molecule and cancer cells have an increased demand for sugar to fuel their unregulated growth. When in the area surrounding the cells, the vitamin C molecule reacts with a metal ion such as iron or copper and forms a hydrogen peroxide molecule that damages the cancer cell.
The conventional wisdom is that vitamin C improves health in part because it can act as an antioxidant, preventing or delaying some types of cell damage. However, Dr. Cantley and his colleagues discovered that the opposite was true in regards to high-dose vitamin C’s therapeutic effects for the KRAS and BRAF forms of colorectal cancer — they occur as a result of inducing oxidation in these cancer cells.
In an oxygen-rich environment such as human arteries, a fraction of vitamin C, also called ascorbic acid, becomes oxidized and is transformed into a new compound called dehydroascorbic acid (DHA). Scientists have known for some time that a specific membrane protein, known as glucose transporter GLUT1, enables both glucose and DHA to enter cells — an activity not afforded to ascorbic acid. But it was less clear what DHA does once inside the cells.
In the study, investigators show that DHA acts like a Trojan horse. Once inside, natural antioxidants inside the cancer cell attempt to convert the DHA back to ascorbic acid; in the process, these antioxidants are depleted and the cell dies from oxidative stress.
“While many normal cells also express GLUT1, KRAS-mutant and BRAF-mutant cancer cells typically have much higher levels since they require a high rate of glucose uptake in order to survive and grow,” Dr. Cantley said. “Also, KRAS and BRAF mutant cells produce more reactive oxygen species than normal cells and therefore need more antioxidants in order to survive. This combination of characteristics makes these cancer cells far more vulnerable to DHA than normal cells or other types of cancer cells.”
Although Dr. Cantley cautioned that these results need to be evaluated in the setting of a human clinical trial, the pre-clinical findings may offer a promising new treatment strategy for the KRAS or BRAF forms of the disease, perhaps as part of a combination therapy. The investigators say their study could lead to the development of new biomarkers that could help physicians determine who would most benefit from treatment. These insights may also have implications for other hard-to-treat cancers that express high levels of GLUT1 transporter, such as renal cell carcinoma, bladder cancer and pancreatic cancer.
Vitamin C has multiple effects on cellular functions in addition to its anti- or pro-oxidant functions, so it will be important to study the effects of high-dose vitamin C on normal and immune cells, said lead author Dr. Jihye Yun, a postdoctoral fellow in Dr. Cantley’s lab.
Some human studies of high-dose IV vitamin C in patients with cancer have shown improved quality of life, as well as improvements in physical, mental, and emotional functions, symptoms of fatigue, nausea and vomiting, pain, and appetite loss (see
“Further study is definitely needed to expand our understanding of these processes. But now that we know the mechanisms, we can utilize the knowledge wisely to get the desired effects,” she said.
“This is not a therapy that you would want to wander into blindly without knowledge of what is going on in your tumor,” Dr. Cantley added.
Dosing recommendations also need to be determined. Therapeutic benefit would likely require intravenous injections, as oral doses are not absorbed efficiently in the intestine to achieve the high serum concentration of vitamin C needed to cause toxicity to these cancer cells. Recent phase I clinical trials conducted on humans to test toxicity have shown that intravenous infusion of vitamin C at doses that converted to similar levels of serum as the Cantley mice trials had good safety profiles.
The dosage and route of administration of vitamin C is essential to determine if it has a direct anti-tumour action or a supportive, antioxidant function. The levels needed to achieve direct tumorcidal effects are at least 200-1000 micromol/L. To achieve these higher anti-cancer levels, IV doses of 25-50 grams are required. 50 grams of IV vitamin C can achieve a plasma level of over 14,000 micromol/L. Oral supplementation is insufficient due to very limited absorption in the digestive tract. Plasma vitamin C levels peak after 200 mg of oral supplementation, and maximal oral dosing before loose stools occur is around 4 grams. Oral absorption can be increased if doses are split up during the day, taken with a meal, or in a sustained released formula. Even when using the same 10 gram dose, intravenous administration achieved a 50-150 fold greater plasma vitamin C level compared to oral supplementation.
Vitamin C (and in turn hydrogen peroxide) levels peak within 30 minutes after IV administration and then return to normal within 24 hours. This makes the direct anti-cancer treatment effective for only a short period time and therefore frequent treatments are needed. The benefit of this is that other therapies can be used in short succession after vitamin C without fear of interactions. Most integrative oncologists recommend IV treatments once or twice a week, with oral supplementation on all the other days, for at least 12 months, with regular lab testing to assess tumour markers and progression.
“Our hope is that our study will inspire the scientific community to take a fresh look at this safe and inexpensive natural molecule and stimulate both basic and clinical research regarding vitamin C as a cancer therapy,” Dr. Yun said.
Article sources:
sciencemag.org
sciencedaily.com
whitakerwellness.com
preventdisease.com
source.http://worldtruth.tv/iv-vitamin-c-will-stop-growth-of-aggressive-forms-of-cancer/

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Tuesday, June 6, 2017

John the Don Motu Patlu Compilation Part 5 30 Minutes of Fun!

John the Don Motu Patlu Compilation Part 5 30 Minutes of Fun!


Watch John the Don - Motu Patlu Compilation - Part 5 - 30 Minutes of Fun!


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Saturday, May 27, 2017

It was the best of Wednesdays it was the worst of Wednesdays

It was the best of Wednesdays it was the worst of Wednesdays


Remember how I said Id have more details regarding my upcoming appearance at River City Bicycles in Portland?  Well now I do, and theyre fantastic:


You can find out more on a popular social network called Facebook, and I hope to see you there.  Its been a few years since Ive been to Portland, and Im looking forward to returning since the more time that passes the more Im convinced Portland doesnt really exist and that I simply dreamt it.

And dont forget University Bookstore in Seattle on June 17th and Rivendell (or, more accurately, the Marriott) in Walnut Creek, CA on June 18th.

As you can see, Im taking the Bay Area and the Pacific Northwest by storm, or at the very least by light rain.

Moving on, yesterday we took a look at an article about the quasi-ineffable notion of "ride quality," and in the comments section of that article someone shared a link to this story from a 1996 issue of Bicycle Guide:


Basically, Antonio Mondonico made seven otherwise identical bikes from different tubing to see if riders could tell the difference, and heres the upshot:

If the numbers on the bikes were switched around and I were to test each bike again, my guess is that Id come up with different tubing preferences.  I think my ride impressions were essentially random.

Though obviously the bike media prefers to pretend this isnt the case because otherwise the glossy magazines would look like this:


I should point out Id happily subscribe to that magazine, but Im probably in the minority, and I suspect manufacturers (or, more accurately, decal designers) of plastic bicycles would be loath to advertise in it.

This is not to say there are no differences between bicycles, because of course there are.  Its just that these differences are largely matters of components and geometry.  Consider Stokbikes, for example, which is the fixie that works like a flounder:



Stokbikes is the branchild of Michael, a.k.a. "Michael the Bicycle Man:"



"Im Michael, and I love bicycles.  They call me Michael the Bicycle Man."

I bet they do.

Cue his theme, sung to the tune of "Popeye the Sailor Man:"

Im Michael the Bicycle Man
Im living in Amsterdam
My smugness unblemished
Cause Im speaking Flemish
Im Michael the Bicycle Man!

Yeah, I know he lives in Utrecht and not Amsterdam, and that Utrecht is not in Flanders, but whatever.  Im American, and therefore stupid.  Plus, I was afraid if I made it too guttural I might blow out my epiglottis while trying to sing it.

Anyway, apparently thin bikes are the new fat bike:


How thin?  Twenty-one euro-inches to be exact:


Now thats thin:


("Only 21 centimetri wide?  Ha!  How you say, Eees it eeen yet?")

Thanks to Stokbikes, you can now keep your fixie behind the sofa, in the coat closet, or even inside your in-wall ironing board hideaway.  The secret is the folding pedals, which are made from recycled Motorola Star Tacs:


And which are also magnetic for some reason:


As well as the rotating stem:


Which of course has already been done, because everything in the world has already been done.

Anyway, now you can store your flat bike flush against the wall of your airy, fashionable office or storefront:


And dont forget to add a wall peg to hang your collapsible helmet from, Flat Stanley.

Finally, in far more depressing news, youve probably heard about this by now:


Five bicyclists were pronounced dead at the scene, and the others were hospitalized with serious injuries, Mr. Getting said. All of the victims were adults, he said.

Three law enforcement agencies received calls about a pickup truck driving erratically about 30 minutes before the crash, Mr. Getting said.

Note the headline says "Pickup Truck Crashes Into Them," perpetuating the notion that motor vehicles are naturally occurring free-roaming organisms that occasionally run into people of their own volition--though this is not even remotely as bad as calling the incident a "biking accident:"

Wow, what a bunck of fucking morons.  Not just "accident," but "biking accident."  These are the same morons, I might add, who thought Bicycle Day was a cycling holiday:


Anyway, drivers are mowing people down constantly, and its worth noting that it takes what is essentially a mass murder to get the national media to notice--and even then, its a "biking accident."  Meanwhile, American drivers are killing over 30,000 people a year (themselves included of course), yet there are more security measures in place for watching HBO GO than there are for getting behind the wheel of a motor vehicle.  At this point you should have to file your driving plans beforehand and enter an access code in order to start your car, but instead we get Chevy ads in articles about someone killing five cyclists with a Chevy:


Fuck it, Im leasing a...nevermind.

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Jury finds Cellectis meganuclease claims invalid but infringed by Precision Biosciences under Doctrine of Equivalents

Jury finds Cellectis meganuclease claims invalid but infringed by Precision Biosciences under Doctrine of Equivalents




As reported in an earlier post, on March 1, 2011, Cellectis sued Precision Biosciences in the District Court of Delaware [CIV-No.-11-173] for allegedly infringing US patent number 7,897,372, directed to "I-CreI Meganuclease Variants with Modified Specificity.”   The companies are both attempting to commercialize engineered meganucleases for use in genetic engineering. The litigation between Cellectis and Precision Biosciences has come to include 20 distinct lawsuits filed in Delaware and Eastern North Carolina (Precision licenses its patents from Duke University), and to involve multiple patents owned by both companies, a couple of which were discussed in this earlier post.


On May 3, the jury issued a verdict with respect to asserted claims 37, 40 and 50 from the ‘372 patent, finding all of the claims invalid for obviousness and inadequate written description. The jury also found that none of the claims are literally infringed by Precision’s meganucleases, and that Precision is not liable for inducing or contributory infringement of the claims. The jury did find that Precision meganucleases infringe claims 37 and 50 under the doctrine of equivalents.

Here are the claims:

37. A recombinant monomer of an I-CreI meganuclease variant comprising at least one mutation in the amino acid sequence of SEQ ID NO: 70, wherein said at least one mutation comprises a substitution at one or more of the amino acids residues at positions 44, 68 and 70 and said monomer further comprises at least one additional mutation of an amino acid residue directly contacting a DNA target sequence wherein said amino acid residue directly contacting a DNA target sequence is selected from the group consisting of positions 26, 28, 30, 32, 33 and 38, wherein said monomer when in a dimeric form is able to cleave DNA.


40. The monomer of an I-CreI meganuclease variant of claim 37, wherein said monomer when in a dimeric form has a modified DNA cleavage specificity relative to the I-CreI meganuclease of SEQ ID NO: 70 in at least one nucleotide in the .+-.3 to 5 triplets.

50. A single-chain chimeric meganuclease comprising the fusion of two different monomers according to claim 37.


Earlier, on April 9, 2013, the District Court issued an order denying multiple motions on summary judgment, including one relating to literal infringement of Claim 40. In one interesting aspect of the decision, the District Court judge held that the term "variant of the wild-type monomer from 1-Crel"  (which appears in the preamble of claim 37, from which claim 40 depends) is an indefinite “limitation,” essentially because the court found that one of skill in the art would not be able to discern the breath of the term "variant." The court pointed out that the claim does not limit the number of mutations that could be present in the amino acid sequence of the claimed “variant,” and it is unclear at what point the number of mutations would cause the sequence to diverge so substantially from wild- type as to no longer constitute a "variant" of the wild type protein, but rather a distinct protein.  The use of this sort of open-ended "variant" language is not uncommon in patent claims of this type.


It will be interesting to follow this case if it is appealed to the Federal Circuit, particularly with respect to the issue of infringement under the doctrine of equivalents. The most important Federal Circuit precedent in this area of which I am aware comes from Genentech v. Wellcome, a 1994 decision in which the Federal Circuit reversed a jurys verdict which found a claim reciting tissue plasminogen activator (t-PA) infringed under the doctrine of equivalents by a substantially re-engineered, synthetic version of t-PA (marketed as a pharmaceutical). The allegedly infringing product differed substantially in structure from the claimed protein, with 15% fewer amino acids and 10-fold greater half-life. In a concurrence, Judge Lourie pointed out that while the traditional "function-way-result" test for infringement under the doctrine of equivalents might work well for some inventions, such as in the mechanical arts, it seems a poor fit for inventions like recombinant proteins.


 


 


 


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Friday, May 26, 2017

Is Getting Rid of Performance Reviews Really a Good Thing

Is Getting Rid of Performance Reviews Really a Good Thing


The Huffington Post reports today on a new study about employee performance reviews by CEB, a consulting firm that offers talent management solutions to its clients.   In recent years, some firms have chosen to do away with the traditional annual performance review.   Some good reasons exist for eliminating these reviews, as the process often does not deliver desired results.  CEB finds, however, that eliminating such review systems may do more harm than good.  Here is an excerpt from the CEB report of their findings:

What’s more, the improvements in measures of employee performance that companies expect actually fall because managers struggle to make and communicate performance and pay decisions without ratings. In fact, less than 5% of managers are able to effectively manage employees without ratings. CEB analysis shows that eliminating ratings leads to four unintended outcomes.
  • Manager conversation quality declines by 14% because managers struggle to explain to employees how they performed in the past and what steps to take to improve future performance.
  • Managers have more time, but time spent on informal conversations decreases by 10 hours because managers do not shift that extra time toward ongoing, informal performance conversations.
  • Top performers’ satisfaction with pay differentiation decreases by 8% because managers have trouble explaining how pay decisions are made and linked to individual contributions.
  • Employee engagement drops by 6% because managers are unable to do the very things that are proven to engage employees, such as set expectations for their, hold clear performance and development conversations, and provide appropriate rewards and recognition.
In sum, the theory of removing the annual review process is that more frequent, informal feedback could be more effective than an annual "event" at which managers employ a formal ratings system to evaluate and rank employees.   In reality, it appears that many managers simply do not provide sufficient feedback when formal annual review systems are eliminated.  Perhaps we should not be surprised by these findings.   Many managers would rather jump in the water off the Maine coast in January than deliver feedback to their subordinates!   

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Wednesday, May 24, 2017

Jane Austen and the Black Hole of British History

Jane Austen and the Black Hole of British History


JANE AUSTEN AND THE BLACK HOLE OF BRITISH HISTORY
Colonial rapacity, holocaust denial and the crisis in biological sustainability
by Gideon Maxwell Polya

CONTENTS

1. Introduction - truth, reason, science and history [ 1 ]
2. The editing of Jane Austen’s connections - the Leighs and Brydges [ 8 ]
3. The editing of the Austens and consequences of rustic amusement [ 18 ]
4. Jane Austen’s siblings and their descendants [ 27 ]
5. The editing of Jane Austen’s life [ 33 ]
6. The rare intrusion of humble social reality into Jane Austen’s novels [ 42 ]
7. The sensibility of Jane Austen’s literary contemporaries [ 56 ]
8. The judgement of Jane Austen’s peers and successors [ 66 ]
9. The East India Company, the Black Hole and the conquest of Bengal [ 75 ]
10. The Great Bengal Famine of 1769-1770 [ 88 ]
11. Warren Hastings and the conquest of India [ 99 ]
12. The impeachment of Warren Hastings and the judgement of history [ 106 ]
13. Colonial famine, genocide and ethnocide [ 114 ]
14. The Bengal Famine of 1943-1944 [ 133 ]
15. Pride and Prejudice - Churchill, Science, the Bengal Famine and the Jewish Holocaust [ 148]
16. Global warming and the unthinkable world of 2050 [ 166 ]
17. Antipodean epilogue - the moral dimension of the Lucky Country and the world [ 174 ]
Notes [ 199 ]
Bibliography [ 227 ]
Index [ 252 ]
Dr Gideon Polya was an Associate Professor in Biochemistry, La Trobe University, Bundoora, Victoria, Australia. The author of over 100 scientific publications, Dr. Polya is presently a Melbourne-based researcher, writer and lecturer. The views expressed in the book are those of the author, Dr. G.M. Polya. This first edition of the book (ISBN 0-646-35580-5) was published in May 1998 by G.M. Polya, 29 Dwyer Street, Macleod, Melbourne, Victoria, 3085, Australia. It is out of print but copies are to be found in some major libraries. A second edition is envisaged.

ESSENCE OF THE BOOK:

Repetition of immense crimes against humanity such as the World War 2 Holocaust is made less likely when the responsible society acknowledges the crime, apologizes, makes amends and accepts the injunction “Never again”.
This book is concerned in part with the 2 century holocaust in British India that commenced with the Great Bengal Famine of 1769-1770 (10 million victims), concluded with the World War 2 Bengal Famine (4 million victims) and took tens of millions of lives in between.
However these events have been almost completely written out of history and removed from general perception, there has been no apology nor amends made and indeed it is generally accepted that, in the absence of effective global action, these horrors will be repeated on an unimaginably larger scale in the coming century.
This carefully documented “J’accuse” addresses what the author terms the “Austenizing” of history or the deletion of awful realities from historical writing.
While it was legitimate for Jane Austen, the artist, to render her exquisite novels free of the contemporary awfulness in which her connections participated, the Austenizing of British history is a holocaust-denying outrage that threatens humanity.

CHAPTER BY CHAPTER SYNOPSIS:

Chapter 1: History ignored yields history repeated; the victor writes history; historians like scientists must respect the basic data; the “Austenizing” of British history or the deletion of awful or embarrassing realities from British historiography (most notably the effective deletion of 2 centuries of horrendous famines in British India culminating in the “forgotten holocaust” of World War 2 Bengal); the British Anglo-Celtic Christian, Austro-Hungarian Jewish and Bihari-Bengali Hindu-Muslim antecedents of the author’s children; the post-Holocaust injunction of “Never again” applied to the “forgotten holocausts” of British India and the looming spectre of mass starvation in the coming century.

Chapter 2: The Austenizing of the maternal connections of Jane Austen; James Brydges and wealth from colonialism and imperialist wars; Indian connections and the theft charge against Jane Austen’s aunt Jane Leigh-Perrot.

Chapter 3: The Austenizing of the paternal connections of Jane Austen; the productive adultery of Warren Hastings, first Governor-General of India, with Jane Austen’s aunt Philadelphia Hancock; transplanting Jane Austen country to Tasmania and consequent ecocide and genocide.

Chapter 4: The Austenizing of Jane Austen’s siblings and their descendants; recurrent consanguinity; the British imperial and Indian involvements of Jane Austen’s family.

Chapter 5: Jane Austen’s life; remarkable differential reportage of Jane Austen’s life and connections.

Chapter 6: The exclusion of any awfulness and the rare intrusion of humble social reality into Jane Austen’s novels; succinct synopses and social content analysis of Jane Austen’s major works; recurrent consanguinity; Sense and Sensibility an Indian-connected novel that barely disguises the affair of Warren Hastings with Jane Austen’s aunt in Bengal; a powerful message from Jane Austen’s exquisite writing - “No matter what our place in the world, we are all empowered by the dignified, intelligent and articulate use of words”.

Chapter 7: The sensitivity of Jane Austen’s literary contemporaries to domestic and colonial abuses of humanity; George Crabbe, Oliver Goldsmith, William Cowper, Robert Burns, Samuel Johnson, Richard Brinsley Sheridan, Lord Byron and Lord Teignmouth; limited British literary responses to the invasion and oppression of India and the Great Bengal Famine of 1769-1770.

Chapter 8: Literary criticism of Jane Austen; Jane Austen and the feminist perspective; the Jane Austen industry; Jane Austen and British imperialists; Jane Austen’s artistically legitimate exclusion of awfulness from her exquisite novels has been quite illegitimately taken by 2 centuries of British historians as a paradigm for the Austenizing or comprehensive white-washing of British history.

Chapter 9: The East India Company; the Black Hole of Calcutta story as grossly exaggerated, historically dubious, Imperial mythology - a Big Lie of British History that demonized Indians and helped to justify 2 centuries of oppression and famine; Siraj-ud-daulah, Clive and the conquest of Bengal.

Chapter 10: The genesis, course and extended aftermath of the Great Bengal Famine of 1769-1770; 10 million victims; a rich country rendered desolate as observed by Jane Austen’s connections; rapacious taxation and mass human starvation; effective deletion of the Great Bengal Famine from British history.

Chapter 11: Warren Hastings, first Governor-General of India and actual father of Jane Austen’s cousin and sister-in-law Eliza De Feuillade (née Hancock); rapacious taxation of famine-devastated Bengal; the Rohilla War, the judicial murder of Nandkumar, conflict with Mysore, Hyderabad and the Marathas, the robbing of the Begums of Oudh and the devastation of Oudh by war, taxation and consequent famine; Hastings’ duel with his foe Philip Francis (that resurfaces in Jane Austen’s Sense and Sensibility).

Chapter 12: The impeachment and trial of Warren Hastings by the British Parliament - Britain’s only equivalent of a major war crimes trial over the abuses of British imperialism; Sheridan’s great speeches; the acquittal of Hastings; the judgement of history and the Austenizing of British imperial crimes.

Chapter 13: 2 centuries of appalling, recurrent famine in British India from 1769 to 1945; comparison of recurrent famine under the British in dry Rajasthan and lush Bengal; British colonial slavery, oppression, famine, genocide and ethnocide in Asia, Africa, the Americas, Oceania, Australia and indeed in Britain and Ireland; the crimes of other imperialist powers; Charles Trevelyan and famine in Ireland and India; the genocide of the Tasmanian aborigines.

Chapter 14: The genesis, war-time context and appalling actuality of the Bengal Famine of 1943-1944; loss of rice from Burma, catastrophic war-time decrease in Indian food imports, food exports, temporary seizure of rice stocks, seizure and destruction of boats, Indian provincial food supply autonomy, no famine declaration, hoarding, British unresponsiveness, drastic cuts to Indian Ocean shipping, catastrophic rice price rises leading to mass starvation; British Military Labour Corps and civilian sexual exploitation of famine victims including children; Wavell, Mountbatten and Casey and final responses to the famine; the 1943-1946 excess mortality of about 4 million Bengalis due to famine and attendant disease; the documenting of the famine and the effective deletion of the famine from history and from general public perception.

Chapter 15: Churchill, World War 2, the Bengal Famine and the Jewish Holocaust; Churchill’s life and his hatred for Indians; Churchill and British air defence, knowledge of the indefensibility of Singapore, Japanese entry into the War and fore-knowledge of the attack on Pearl Harbor; Churchill, Lindeman, the importance of proper scientific advice to government, the air war in Europe, the Battle of the Atlantic, the shipping crisis and famine in India; famine as a strategic weapon to control restless subjects; Muslim containment, the Middle East, oil, the refusal to allow Jewish escape from Europe, the Jewish Holocaust and the forgotten, substantially Muslim Holocaust of Bengal; Churchill’s contribution to Muslim-Hindu antipathy as his final legacy to India; the effective deletion of the Bengal Famine from history and general public perception.

Chapter 16: Global warming and sea level, human health and tropical versus temperate agricultural productivity consequences; population growth, global agricultural sustainability and the growing discrepancy between population and food supply; the crisis in biological sustainability.

Chapter 17: Unresponsiveness of the world to the World War 2 Jewish Holocaust and to the “forgotten holocaust” of the Bengal Famine; examination of liberal, democratic, highly-educated and prosperous Australia (the Lucky Country) by way of assessment of the likelihood of timely global response to the impending environmental, population and sustainable food production crisis of the coming century; pre-invasion aboriginal Australia, invasion and genocide, racism of White Australia, the apogee of social decency in Australia and the current resurgent racism towards aboriginals and Asians; genocide, ethnocide, ecocide and terracide in Australia and unresponsiveness to the global crisis; a recent experimental test of the moral responsiveness of prosperous, liberal, democratic Australia - the war-time Bengal Famine (accounting for about 90% of World War 2 British Empire military plus civilian casualties) continues to be effectively ignored and thus removed from public perception by the ostensibly liberal political, media, academic and intellectual Establishment of Australia (and of Britain); how we can prevent the looming disaster - peri-conception, male sex selection as an example of a humane, non-invasive, pro-choice mechanism to reduce population (empirical evidence being provided by Fiji, a very tolerant and peaceful multi-racial society that developed from an initially large male over female imbalance among the Indian “indentured slaves”); further civilized contributions include the childless, culturally-absorbed Jane Austen option, tolerance of homosexuality and profound sympathy for the richness of the world as exhibited by Third World small-holder and aboriginal societies.

THE BOTTOM LINE:

The world is facing a crisis in biological sustainability due to the connected problems of excessive and increasing population, profligate use of resources and remorseless environmental degradation. Near-comprehensive holocaust denial in our culture in relation to several centuries of recurrent, horrendous famines in British India has blunted our responsiveness to such man-made catastrophes and continues to contribute to the global failure to face up to avoidable mass starvation in the coming century. The world must resolutely apply the post-Holocaust injunction of “Never again” to these past events and take incisive steps to avoid repetition in the future.

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Sunday, May 21, 2017

Is There Only One Right Answer A Challenge to the Teaching of Math and Science in Higher Ed

Is There Only One Right Answer A Challenge to the Teaching of Math and Science in Higher Ed




Many current promoters of MOOCs and other distance education models argue that higher education can be taught in a much more efficient way in fields like computer science, math, biology, and chemistry. According to high-tech educators, the main reason why these important disciplines can be streamlined is that there is only one right answer to questions and tests, and so a computer can easily grade these courses.  On a most basic level, they claim that 2+2 will always equal 4, and thus, there is no need for creativity, critical thinking, or interactive discussions.


The problem with this logic is that it removes the STEM disciplines from any social, personal, or ethical context.  In other words, students learn that math and science are impersonal, value-free fields founded on established, unchallengeable truths.  While it is clear that students do need to learn basic formulas and concepts, all knowledge needs to be seen in its social and historical contexts.  In fact, not only do we want students to think critically about the information they learn inside and outside of their classes, but we also need to train scientists and engineers to be innovative and creative.  Moreover, with the increasing importance of issues like alternative energy, cloning, stem cell therapy, and climate change, science and math should be approached with ethical concerns front and center. 


Purveyors of MOOCs like to say that online classes will not be any worse than the large lecture classes that dominate the undergraduate curriculum, and they have a point when they make this argument; however, we do not need a race to the bottom: what we need is to re-commit universities and colleges to spending resources on undergraduate instruction.  Whether our goal is to compete in the global high-tech economy or train future citizens and responsible adults, higher education cannot be focused on simply transmitting and testing simplified facts and calculations.  In fact, it is surprising that many of the most ardent promoters of MOOCs are themselves innovative computer scientists who think outside of the established box.


While China sends its students to American universities in order to build a creative class, it is ironic that the U.S. is seeking to dumb down its own curriculum. As I often tell my students, it is rare in life that you are confronted with one right answer or a simple multiple-choice test.  Reality is far too complex for the reductive model of education that is often tied to MOOCs and a reductive vision of the STEM disciplines. 


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Saturday, May 20, 2017

Jack of all trades

Jack of all trades


In recent years, there is a new trend in the world, and not only in the physical training world, but everywhere, concerning trying to achieve many goals at the same time, conquering the title Jack of all trades.
I believe this is fine... As a goal!
As the way to get to that goal, it is far from optimal.
Our phisiolegy just doesnt work that way. SAID principle, adaptation, specialization and survivle mechanisms are main factors here, but I wont lecture you on that.
Recently I ran into a training program that is highly flawed by a generaly excelent strength coach, Christian Thibaudeau:
http://www.t-nation.com/free_online_article/sports_body_training_performance_bodybuilding/ill_be_damned_it_works
(ignore the supplement commercial at the start of the article)

Christian, who quotes coach-extraordiner Charles Poliquin is breaking some of Poliquins main rules about program design, among them specialization, broad pyramid sets and more.
Notice the equal quantity of volume divided among the various training
tools, while trying to achieve.... Everything.... And all at the same time.
I suspect this kind of program has no value, besides maybe for the complete beginner and as a general fitness tool. Not very useful.
I see this kind of thing everywhere, people trying to achieve everything
together at the same training micro/macro-cycle while only discovering they have achieved nothing.
Dont throw your adaptive body (and mind) into confusion. Even if you have multiple goals (Im the first to admit that) periodize them wisely, move certain things into maintaince while pushing other things forward, you will see better results, quicker.
Having said that, taking a hypothetical trainee, put him into an intense crossfit program that includes OLifting, gymnasics and metcon work for 3 years and see where he gets. Im sure an impressive improvement in many physical traits.
Take the same trainee and put him one year with a OLifting coach working OL mainly, one year with coach sommer, specializing in gymnastics strength elements and one year of implementation into metcon type of work and you get a much supperior athlete.
Isnt it obvious?

PS. For Coach Thibaudeaus sake, I have to admit I have commited the same sin in program design a few times in the past, it is just our nature to try to juggle all the balls.

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Wednesday, May 17, 2017

Ishqbaaz’s Nakuul Mehta is a fan of Shaheer Sheikh’s work in Kuch Rang Pyar Ke Aise Bhi

Ishqbaaz’s Nakuul Mehta is a fan of Shaheer Sheikh’s work in Kuch Rang Pyar Ke Aise Bhi




In a year when TV’s leading men have been loving and super supportive of their women, Nakuul Mehta’s Shivaay Singh Oberoi in Ishqbaaz has come like a sharp contradiction. The wedding track is the talk of the town. The actor won the Best Actor Award at AVTA 2016 and spoke to Bollywood Life about what makes Shivaay unique and special….


Did you expect the award at AVTA 2016?
To be honest and fair, the character and the show is a good one. It has been well-received by people. I take great pride in whatever I do. So, I was ‘not’ not expecting the honour.


From Shaheer Sheikh in KRPKAB to Vivian Dsena in Shakti, this has been an year for male actors. Who did you feel was your toughest competitor?
As a TV actor, you do not get time to consume your own work. There is hardly any time left to watch what your peers are doing. I used to wonder why film actors say it is tough to catch up on what others are doing but now I realise what they meant. When you are shooting for a show, you are totally into it with very little free time. I have seen bits of Shaheer’s Kuch Rang Pyar Ke Aise Bhi and it I feel it is a very good and realistic show. He has done a great job. Vivian Dsena is a dear friend. All are doing a good job and delivering their best, which is why they are loved.


(Also Read: Ishqbaaz: Anika to give a TIGHT SLAP to Shivaay)


Whom would you give credit to for Shivaay Singh Oberoi?
It is actually full credit to my writers and producers. The makers were willing to bet money on me to play this role when I played a diametrically opposite character in my last show, Pyaar Ka Dard Hai Meetha Meetha Pyaara Pyaara. It took a lot of guts on their side. SSO is totally different from Nakuul. That is what I love about my role…the chance to do be someone who is just not me. I am absolutely loving it. While I do come with a pedigree in real life, I do not share any of SSO’s values and thoughts.


You come from Prithviraj Chauhan’s dynasty. Did you take any inspiration from your forefathers?
I did not consciously look into it. Yes, I do come from an amazingly illustrious background. The walls of my home are adorned with pictures of my forefathers. They fought all the wars. There is a lifesize portrait of my great-grandfather, which is 150 years old. When you see them in their military wear, the sense of royalty unknowningly seeps into you. I was also reading my dad’s novel Guns And Glories while shooting for Ishqbaaz, so maybe sub-consciously I got some reference points.


Shivaay is a total chauvinist. Did the character not bother you in this feminist wave on TV?
As an actor, you choose your own roles. I like to be unabashed. If he is a chauvinist, there is no point in going half way just to keep a few people happy. There are characters like Shivaay in society and as an actor you portray what you see around you. We want people to feel Anika’s pain. It would be selfish to alter the character just to obtain a middle path. We are not making a preachy show but people should and must have problems with someone like Shivay.


 



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Monday, May 15, 2017

Its February The month of Love Time to celebrate the Heart Truth

Its February The month of Love Time to celebrate the Heart Truth




Beginning with National Wear Red Day®—Friday, February 5, 2010—millions helped to spread the critical message that "Heart Disease Doesnt Care What You Wear—Its the #1 Killer of Women.®" The Red Dress®, the national symbol for women and heart disease awareness, was created by The Heart Truth®in 2002 to deliver an urgent wakeup call to American women. Everyone can participate in the national movement by wearing their favorite red dress, shirt, tie, or Red Dress Pin. For free information and resources to help you and your community celebrate National Wear Red Day, visit the National Wear Red Day toolkit.

On Thursday, February 11, 2010, The Heart Truth brought the Red Dress to life once again on the runway at New York Fashion Week with the debut of the Red Dress Collection 2010. This spectacular event reminds women of the need to protect their heart health and inspires them to take action. For the second year in a row, a selection of the designer dresses seen on the runway will be auctioned online in February through a partnership with Clothes Off Our Back. To bid on these Red Dresses this February, visit www.clothesoffourback.org.
Get Involved today: visit the Healthy Action Community, where you can find free tools and resources to help you protect your heart health and share The Heart Truth with others. Be sure to let others know about your event by submitting details to the Activity Registry.
®National Wear Red Day is a registered trademark of HHS and AHA. 


I thought the above information important for all women everywhere to take notice of.  For those of you who are still lighting up a ciggie, you know who you are, this is the year to say quits and breathe easier.




For all my Canajun buddies, good luck to all the participants at the start of the Winter Olympics and keep us updated on the happenings, eh?  Ciao!!


Heres my favorite bad boy who continues to give love a bad name. Bon Jovi live from Londons Wembley Stadium (circa 1995)


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